Ontology highlight
ABSTRACT:
SUBMITTER: Hong Y
PROVIDER: S-EPMC7931243 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Hong Yuan Y Feng Yingcai Y Sun Hanzi H Zhang Bo B Wu Hongfu H Zhu Qing Q Li Yucheng Y Zhang Tong T Zhang Yilu Y Cui Xinxin X Li Zhuo Z Song Xiaomin X Li Kang K Liu Mike M Liu Ye Y
FEBS open bio 20210216 3
Programmed cell death protein 1 (PD-1), an immune checkpoint receptor expressed by activated T, B, and NK cells, is a well-known target for cancer immunotherapy. Tislelizumab (BGB-A317) is an anti-PD-1 antibody that has recently been approved for treatment of Hodgkin's lymphoma and urothelial carcinoma. Here, we show that tislelizumab displayed remarkable antitumor efficacy in a B16F10/GM-CSF mouse model. Structural biology and Surface plasmon resonance (SPR) analyses revealed unique epitopes of ...[more]