Ultrasound has limited diagnostic utility in children with acute lymphoblastic leukemia developing pancreatitis.

ABSTRACT:

Purpose

Acute pancreatitis (AP) due to chemotherapy-induced pancreatic injury is a common side effect of treatment for acute lymphoblastic leukemia (ALL), the most common childhood malignancy. The American College of Radiology recommends ultrasound (US) for initial imaging of AP in all populations to assess for ductal obstruction. However, US may be insensitive to diagnose and assess chemotherapy-associated AP.

Methods and materials

The institutional review board approved this retrospective study. Patients with ALL and AP were identified from protocol databases, using Common Terminology Criteria for Adverse Events (CTCAE) version 3. Chemotherapy dosing, amylase/lipase levels, clinical symptoms, and US/computed tomography (CT) reports within 10 days of diagnosis were recorded

SUBMITTER: Richardson R 

PROVIDER: S-EPMC7931369 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature