Parthenolide Destabilizes Microtubules by Covalently Modifying Tubulin.

ABSTRACT: Detyrosination of the α-tubulin C-terminal tail is a post-translational modification (PTM) of microtubules that is key for many biological processes.¹ Although detyrosination is the oldest known microtubule PTM,^2-7 the carboxypeptidase responsible for this modification, VASH1/2-SVBP, was identified only 3 years ago,^8,9 precluding genetic approaches to prevent detyrosination. Studies examining the cellular functions of detyrosination have therefore relied on a natural product, parthenolide, which is widely believed to block detyrosination of α-tubulin in cells, presumably by inhibiting the activity of the relevant carboxypeptidase(s).¹⁰ Parthenolide is a sesquiterpene lactone that forms covalent linkages predominantly with ex

SUBMITTER: Hotta T 

PROVIDER: S-EPMC7931505 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature