Hindlimb unloading-induced reproductive suppression via Downregulation of hypothalamic Kiss-1 expression in adult male rats.

ABSTRACT:

Background

Spaceflights-induced microgravity can alter various physiological processes in human's body including the functional status of the reproductive system. Rodent model of tail-suspension hindlimb unloading is extensively used to stimulate the organs responses to the microgravity condition. This study explores the potential effects of hindlimb unloading on testicular functions and spermatogenesis in adult male rats and the underlying mechanism/s.

Methods

Twenty Sprague-Dawley rats were allotted into two groups: normally loaded group (control; all arms were in touch with the grid floor) and hindlimb unloaded group (HU; only the forearms were in contact with the grid floor).

Results

Following 30 days of exposure, the HU group saw a decline in body weight, testicu

SUBMITTER: Moustafa A 

PROVIDER: S-EPMC7931529 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature