Visit-to-visit variability of serum uric acid measurements and the risk of all-cause mortality in the general population.

ABSTRACT:

Background

Evidence on longitudinal variability of serum uric acid (SUA) and risk of all-cause mortality in the general population is limited, as many prior studies focused on a single measurement of SUA.

Methods

A total of 53,956 participants in the Kailuan study who underwent three health examinations during 2006 to 2010 were enrolled. Variability of SUA was measured using the coefficient of variation (primary index), standard deviation, average real variability, and variability independent of the mean. Cox proportional hazard regressions were used to calculate the hazard ratio (HR) and 95% confidence interval (CI) for the association of variability of SUA with subsequent risk of all-cause mortality, considering its magnitude and the direction and across different baseline

SUBMITTER: Tian X 

PROVIDER: S-EPMC7931538 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature