Trans-ethnic gut microbial signatures of prediabetic subjects from India and Denmark.

ABSTRACT:

Background

Recent studies have indicated an association of gut microbiota and microbial metabolites with type 2 diabetes mellitus (T2D). However, large-scale investigation of the gut microbiota of "prediabetic" (PD) subjects has not been reported. Identifying robust gut microbiome signatures of prediabetes and characterizing early prediabetic stages is important for the understanding of disease development and could be crucial in early diagnosis and prevention.

Methods

The current study performed amplification and sequencing on the variable regions (V1-V5) of the 16S rRNA genes to profile and compare gut microbiota of prediabetic individuals (N = 262) with normoglycemic individuals (N = 275) from two cohorts in India and Denmark. Similarly, fasting serum inflammatory biomark

SUBMITTER: Pinna NK 

PROVIDER: S-EPMC7931552 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature