The comparative effect of exposure to various risk factors on the risk of hyperuricaemia: diet has a weak causal effect.

ABSTRACT:

Background

Prevention of hyperuricaemia (HU) is critical to the prevention of gout. Understanding causal relationships and relative contributions of various risk factors to hyperuricemia is therefore important in the prevention of gout. Here, we use attributable fraction to compare the relative contribution of genetic, dietary, urate-lowering therapy (ULT) and other exposures to HU. We use Mendelian randomisation to test for the causality of diet in urate levels.

Methods

Four European-ancestry sample sets, three from the general population (n = 419,060) and one of people with gout (n = 6781) were derived from the Database of Genotypes and Phenotypes (ARIC, FHS, CARDIA, CHS) and UK Biobank. Dichotomised exposures to diet, genetic risk variants, BMI, alcohol, diuretic treatmen

SUBMITTER: Topless RKG 

PROVIDER: S-EPMC7931603 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature