Isolation and Pharmacological Characterization of Six Opioidergic Picralima nitida Alkaloids.

ABSTRACT: The seeds of the akuamma tree (Picralima nitida) have been used as a traditional treatment for pain and fever. Previous studies have attributed these effects to a series of indole alkaloids found within the seed extracts; however, these pharmacological studies were significantly limited in scope. Herein, an isolation protocol employing pH-zone-refining countercurrent chromatography was developed to provide six of the akuamma alkaloids in high purity and quantities sufficient for more extensive biological evaluation. Five of these alkaloids, akuammine (1), pseudo-akuammigine (3), akuammicine (4), akuammiline (5), and picraline (6), were evaluated against a panel of >40 central nervous system receptors to identify that their primary targets are the o

SUBMITTER: Creed SM 

PROVIDER: S-EPMC7932029 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature