Multimodal cardiovascular model for hemodynamic analysis: Simulation study on mitral valve disorders.

ABSTRACT: Valvular heart diseases are a prevalent cause of cardiovascular morbidity and mortality worldwide, affecting a wide spectrum of the population. In-silico modeling of the cardiovascular system has recently gained recognition as a useful tool in cardiovascular research and clinical applications. Here, we present an in-silico cardiac computational model to analyze the effect and severity of valvular disease on general hemodynamic parameters. We propose a multimodal and multiscale cardiovascular model to simulate and understand the progression of valvular disease associated with the mitral valve. The developed model integrates cardiac electrophysiology with hemodynamic modeling, thus giving a broader and holistic understanding of the effect of disease progression on various parameters like eje

SUBMITTER: Roy D 

PROVIDER: S-EPMC7932118 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature