A mathematical model of the role of aggregation in sonic hedgehog signalling.

ABSTRACT: Effective regulation of the sonic hedgehog (Shh) signalling pathway is essential for normal development in a wide variety of species. Correct Shh signalling requires the formation of Shh aggregates on the surface of producing cells. Shh aggregates subsequently diffuse away and are recognised in receiving cells located elsewhere in the developing embryo. Various mechanisms have been postulated regarding how these aggregates form and what their precise role is in the overall signalling process. To understand the role of these mechanisms in the overall signalling process, we formulate and analyse a mathematical model of Shh aggregation using nonlinear ordinary differential equations. We consider Shh aggregate formation to comprise of multimerisation, association with heparan sulfate proteogly

SUBMITTER: Derrick DJA 

PROVIDER: S-EPMC7932509 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature