The lymphatic system as a potential mechanism of spread of melioidosis following ingestion of Burkholderia pseudomallei.

ABSTRACT: Burkholderia pseudomallei is the causative agent of melioidosis, which is a Gram negative, facultative intracellular bacterium. Disease is prevalent in SE Asia and in northern Australia, as well as in other tropical and subtropical regions. Recently, there is an increasing awareness of the importance of bacterial ingestion as a potential route of infection, particularly in cases of unexplained origin of the disease. The marmoset is a New World Monkey (NWM) species that is being developed as an alternative NHP model to complement the more traditionally used Old World Monkeys (OWM). Models have been developed for the traditional routes of disease acquisition, subcutaneous and inhalational. This manuscript details the development and characterisation of an ingestion model of melioidosis. Dose

SUBMITTER: Nelson M 

PROVIDER: S-EPMC7932547 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature