Pairing of segmentation clock genes drives robust pattern formation.

ABSTRACT: Gene expression is an inherently stochastic process^1,2; however, organismal development and homeostasis require cells to coordinate the spatiotemporal expression of large sets of genes. In metazoans, pairs of co-expressed genes often reside in the same chromosomal neighbourhood, with gene pairs representing 10 to 50% of all genes, depending on the species^3-6. Because shared upstream regulators can ensure correlated gene expression, the selective advantage of maintaining adjacent gene pairs remains unknown⁶. Here, using two linked zebrafish segmentation clock genes, her1 and her7, and combining single-cell transcript counting, genetic engineering, real-time imaging and computational modelling, we show that gene pairing boosts correlated transcription and pro

SUBMITTER: Zinani OQH 

PROVIDER: S-EPMC7932681 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature