Ontology highlight
ABSTRACT:
SUBMITTER: Mukherjee K
PROVIDER: S-EPMC7932694 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Mukherjee Kaustav K Xue Li L Planutis Antanas A Gnanapragasam Merlin Nithya MN Chess Andrew A Bieker James J JJ
eLife 20210211
Erythroblastic islands are a specialized niche that contain a central macrophage surrounded by erythroid cells at various stages of maturation. However, identifying the precise genetic and transcriptional control mechanisms in the island macrophage remains difficult due to macrophage heterogeneity. Using unbiased global sequencing and directed genetic approaches focused on early mammalian development, we find that fetal liver macrophages exhibit a unique expression signature that differentiates ...[more]