Shi-Zhen-An-Shen Decoction, a Herbal Medicine That Reverses Cuprizone-Induced Demyelination and Behavioral Deficits in Mice Independent of the Neuregulin-1 Pathway.

ABSTRACT: Shi-Zhen-An-Shen decoction (SZASD), a Chinese herbal medicine that is a liquor extracted from plants by boiling, has been reported to be effective in treating schizophrenia. However, the mechanism is unclear. Abnormal demyelination has been implicated in schizophrenia. The aim of this study was to investigate the effect of SZASD on myelin in demyelinated mice exhibiting schizophrenia-like behaviors. Sixty male C57BL/6 mice were randomly divided into six groups (n = 10 per group): (1) control group, (2) cuprizone (CPZ, a copper chelator that induced demyelination, 0.2% w/w)+saline, (3) CPZ+low-dose SZASD (8.65 g·kg^-1·d^-1), (4) CPZ+medium-dose SZASD (17.29 g·kg^-1·d^-1), (5) CPZ+high-dose SZASD (25.94 g·kg^-1·d^-1</

SUBMITTER: Ma C 

PROVIDER: S-EPMC7932787 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature