Influence of the natural hormonal milieu on brain and behavior in women who smoke cigarettes: Rationale and methodology.

ABSTRACT: Women experience more severe health consequences from smoking, have greater difficulty quitting, and respond less favorably to nicotine replacement therapy than men. The influence of fluctuating ovarian hormones, specifically estradiol (E) and progesterone (P), on brain and behavioral responses during exposure to smoking reminders (i.e., cues) may be a contributing factor. Results from our laboratory suggest that women in the late follicular phase of their menstrual cycle (MC) have enhanced smoking cue (SC) vulnerabilities and reduced functional connectivity in neurocircuitry underlying cognitive control, potentially placing them at greater risk for continued smoking and relapse. The primary aim of this study is to examine and link hormonal status with brain and behavioral responses to SCs

SUBMITTER: Wetherill RR 

PROVIDER: S-EPMC7932892 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature