Distinct Stromal and Immune Features Collectively Contribute to Long-Term Survival in Pancreatic Cancer.

ABSTRACT: Background: The aggressive biology and treatment refractory nature of pancreatic ductal adenocarcinoma (PDAC) significantly limits long-term survival. Examining the tumor microenvironment (TME) of long-term survivors (LTS) of PDAC offers the potential of unveiling novel biological insights and therapeutic targets. Methods: We performed an integrated approach involving immunophenotyping, stromal scoring and histomorphological profiling of a cohort of 112 PDAC-cases, including 25 long-term survivors (LTSs, OS ≥ 60 months). Mutational frequencies were assessed using targeted next generation sequencing. Finally, we validated our findings in silico using an external cohort of microarray data from PDAC patients. Results: LTS cases exhibit a largely quiescent populatio

SUBMITTER: Sadozai H 

PROVIDER: S-EPMC7933000 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature