Tracking Response Dynamics of Sequential Working Memory in Patients With Mild Parkinson's Disease.

ABSTRACT: The ability to sequence thoughts and actions is impaired in Parkinson's disease (PD). In PD, a distinct error pattern has been found in the offline performance of sequential working memory. This study examined how PD's performance of sequential working memory unfolds over time using mouse tracking techniques. Non-demented patients with mild PD (N = 40) and healthy controls (N = 40) completed a computerized digit ordering task with a computer mouse. We measured response dynamics in terms of the initiation time, ordering time, movement time, and area under the movement trajectory curve. This approach allowed us to distinguish between the cognitive processes related to sequence processing before the actual movement (initiation time and ordering time) and the execution processes

SUBMITTER: Zhang G 

PROVIDER: S-EPMC7933003 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature