Genetic Ancestry Contributes to Somatic Mutations in Lung Cancers from Admixed Latin American Populations.

ABSTRACT: Inherited lung cancer risk, particularly in nonsmokers, is poorly understood. Genomic and ancestry analysis of 1,153 lung cancers from Latin America revealed striking associations between Native American ancestry and their somatic landscape, including tumor mutational burden, and specific driver mutations in EGFR, KRAS, and STK11. A local Native American ancestry risk score was more strongly correlated with EGFR mutation frequency compared with global ancestry correlation, suggesting that germline genetics (rather than environmental exposure) underlie these disparities. SIGNIFICANCE: The frequency of somatic EGFR and KRAS mutations in lung cancer varies by ethnicity, but we do not understand why. Our study suggests that the variation in EGFR and

SUBMITTER: Carrot-Zhang J 

PROVIDER: S-EPMC7933062 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature