Comparative effectiveness of denosumab, teriparatide, and zoledronic acid among frail older adults: a retrospective cohort study.

ABSTRACT: The comparative effects of zoledronic acid, denosumab, and teriparatide for preventing hip fractures in frail older adults, especially those in nursing homes, were unknown. We found that denosumab and zoledronic acid may be as effective as teriparatide for hip fracture prevention in nursing home residents.

Introduction

Several non-oral drugs exist for osteoporosis treatment, including zoledronic acid (ZA), denosumab, and teriparatide. Little data exist on the comparative effectiveness of these drugs for hip fracture prevention in frail older adults. We examined their comparative effectiveness in one of the frailest segments of the US population-nursing home (NH) residents.

Methods

We conducted a national retrospective cohort study of NH residents aged ≥ 65 years using 2012 to

SUBMITTER: Zullo AR 

PROVIDER: S-EPMC7933063 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature