3D Registration of pre-surgical prostate MRI and histopathology images via super-resolution volume reconstruction.

ABSTRACT: The use of MRI for prostate cancer diagnosis and treatment is increasing rapidly. However, identifying the presence and extent of cancer on MRI remains challenging, leading to high variability in detection even among expert radiologists. Improvement in cancer detection on MRI is essential to reducing this variability and maximizing the clinical utility of MRI. To date, such improvement has been limited by the lack of accurately labeled MRI datasets. Data from patients who underwent radical prostatectomy enables the spatial alignment of digitized histopathology images of the resected prostate with corresponding pre-surgical MRI. This alignment facilitates the delineation of detailed cancer labels on MRI via the projection of cancer from histopathology images onto MRI. We introduce a framewo

SUBMITTER: Sood RR 

PROVIDER: S-EPMC7933126 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature