Skeletal muscle ferritin abundance is tightly related to plasma ferritin concentration in adults with obesity.

ABSTRACT:

New findings

What is the central question of this study? Obesity is associated with complex perturbations to iron homeostasis: is plasma ferritin concentration (a biomarker of whole-body iron stores) related to the abundance of ferritin (the key tissue iron storage protein) in skeletal muscle in adults with obesity? What is the main finding and its importance? Plasma ferritin concentration was tightly correlated with the abundance of ferritin in skeletal muscle, and this relationship persisted when accounting for sex, age, body mass index and plasma C-reactive protein concentration. Our findings suggest that skeletal muscle may be an important iron store.

Abstract

Obesity is associated with complex perturbations to whole-body and tissue iron homeostasis. Recent evidence sugg

SUBMITTER: Ryan BJ 

PROVIDER: S-EPMC7933310 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature