^99mTc-labelled PSMA ligand for radio-guided surgery in nodal metastatic prostate cancer: proof of principle.

ABSTRACT:

Purpose

Intraoperative identification of prostate cancer (PCa) lymph node (LN) metastases (LNM) detected by preoperative PSMA PET/CT may be facilitated by PSMA radio-guided surgery (RGS) with use of a γ-probe. Earlier we demonstrated excellent performance of the ¹¹¹In-labelled PSMA ligand DKFZ-617 ([¹¹¹In]In-PSMA-617) in RGS for ex situ distinction of LN vs LNM at lymphadenectomy (LA) at a single LN level. In comparison with indium-111, technetium-99m has better physical properties for γ-probe measurements, better availability and lower radiation exposure for patients and medical personnel. Against this background, we evaluated the uptake of ^99mTc-PSMA-I&S ligand at the level of single LN and its power to discriminate between unaffected LN and LNM.<

SUBMITTER: Mix M 

PROVIDER: S-EPMC7933311 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature