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Neolignans and Norlignans from Insect Medicine Polyphaga plancyi and Their Biological Activities.

ABSTRACT: Ten neolignans or norlignans (1-10) including eight new compounds were isolated from the whole bodies of Polyphaga plancyi Bolivar. Their structures were identified by spectroscopic data. Compounds 3, 4, 8, and 9 are racemates indicated by chiral HPLC analysis. Chiral separation followed by ECD calculations allowed to clarify the absolute configurations of all the antipodes. All the new compounds were evaluated for their biological properties toward extracellular matrix in rat renal proximal tubular cells, human cancer cells (K562, A549, and Huh7), EV71, ROCK2, JAK3, DDR1, and coagulation.

SUBMITTER: Zhu HJ

PROVIDER: S-EPMC7933325 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Neolignans and Norlignans from Insect Medicine Polyphaga plancyi and Their Biological Activities.

Zhu Hong-Jie HJ Xu Te T Yan Yong-Ming YM Tu Zheng-Chao ZC Cheng Yong-Xian YX

Natural products and bioprospecting 20200902 1

Ten neolignans or norlignans (1-10) including eight new compounds were isolated from the whole bodies of Polyphaga plancyi Bolivar. Their structures were identified by spectroscopic data. Compounds 3, 4, 8, and 9 are racemates indicated by chiral HPLC analysis. Chiral separation followed by ECD calculations allowed to clarify the absolute configurations of all the antipodes. All the new compounds were evaluated for their biological properties toward extracellular matrix in rat renal proximal tub ...[more]

PMID: 32876846

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Neolignans and Norlignans from Insect Medicine Polyphaga plancyi and Their Biological Activities.

Publications

Neolignans and Norlignans from Insect Medicine Polyphaga plancyi and Their Biological Activities.

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