Serial transplantation unmasks galectin-9 contribution to tumor immune escape in the MB49 murine model.

ABSTRACT: Mechanisms of tumor immune escape are quite diverse and require specific approaches for their exploration in syngeneic tumor models. In several human malignancies, galectin-9 (gal-9) is suspected to contribute to the immune escape. However, in contrast with what has been done for the infiltrating cells, the contribution of gal-9 produced by malignant cells has never been demonstrated in an animal model. Therefore, we derived isogenic clones-either positive or negative for gal-9-from the MB49 murine bladder carcinoma cell line. A progressive and consistent reduction of tumor growth was observed when gal-9-KO cells were subjected to serial transplantations into syngeneic mice. In contrast, tumor growth was unaffected during parallel serial transplantations into nude mice, thus linking tumor

SUBMITTER: Baloche V 

PROVIDER: S-EPMC7933353 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature