Phenotypic Characterization and Brain Structure Analysis of Calcium Channel Subunit α₂δ-2 Mutant (Ducky) and α₂δ Double Knockout Mice.

ABSTRACT: Auxiliary α₂δ subunits of voltage-gated calcium channels modulate channel trafficking, current properties, and synapse formation. Three of the four isoforms (α₂δ-1, α₂δ-2, and α₂δ-3) are abundantly expressed in the brain; however, of the available knockout models, only α₂δ-2 knockout or mutant mice display an obvious abnormal neurological phenotype. Thus, we hypothesize that the neuronal α₂δ isoforms may have partially specific as well as redundant functions. To address this, we generated three distinct α₂δ double knockout mouse models by crossbreeding single knockout (α₂δ-1 and -3) or mutant (α₂δ-2/ducky) mice. Here, we provide a first phenotypic description and brain structure analysis. We

SUBMITTER: Geisler SM 

PROVIDER: S-EPMC7933509 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature