Altered Gut Microbiota Related to Inflammatory Responses in Patients With Huntington's Disease.

ABSTRACT: Emerging evidence indicates that gut dysbiosis may play a regulatory role in the onset and progression of Huntington's disease (HD). However, any alterations in the fecal microbiome of HD patients and its relation to the host cytokine response remain unknown. The present study investigated alterations and host cytokine responses in patients with HD. We enrolled 33 HD patients and 33 sex- and age- matched healthy controls. Fecal microbiota communities were determined through 16S ribosomal DNA gene sequencing, from which we analyzed fecal microbial richness, evenness, structure, and differential abundance of individual taxa between HD patients and healthy controls. HD patients were evaluated for their clinical characteristics, and the relationships of fecal microbiota with these clinical cha

SUBMITTER: Du G 

PROVIDER: S-EPMC7933529 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature