Indolaminergic System in Adult Rat Testes: Evidence for a Local Serotonin System.

ABSTRACT: Serotonin (5-HT) is member of a family of indolamine molecules that participate in a wide variety of biological processes. Despite its important role in the regulation of local blood systems, little is known about the physiological function of 5-HT in reproductive organs, its functional implications, and its role in the reproduction of mammals. In the present work, we evaluated the localization and distribution of 5-HT (using histochemical analysis of indolamines) and different components of the serotoninergic system in rat testes. We detected local synthesis and degradation through immunofluorescence and western blot analyses against the TPH1, MAO_A, 5-HT_T, and VMAT1 serotonin transporters. We also identified the localization and distribution of the 5-HT_1B,

SUBMITTER: Jimenez-Trejo F 

PROVIDER: S-EPMC7933592 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature