Redox Epiphospholipidome in Programmed Cell Death Signaling: Catalytic Mechanisms and Regulation.

ABSTRACT: A huge diversification of phospholipids, forming the aqueous interfaces of all biomembranes, cannot be accommodated within a simple concept of their role as membrane building blocks. Indeed, a number of signaling functions of (phospho)lipid molecules has been discovered. Among these signaling lipids, a particular group of oxygenated polyunsaturated fatty acids (PUFA), so called lipid mediators, has been thoroughly investigated over several decades. This group includes oxygenated octadecanoids, eicosanoids, and docosanoids and includes several hundreds of individual species. Oxygenation of PUFA can occur when they are esterified into major classes of phospholipids. Initially, these events have been associated with non-specific oxidative injury of biomembranes. An alternative concept is that

SUBMITTER: Kagan VE 

PROVIDER: S-EPMC7933662 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature