Testosterone therapy and bone quality in men with diabetes and hypogonadism: Study design and protocol.

ABSTRACT:

Context

Type 2 diabetes mellitus (T2D) is often accompanied by male hypogonadism and both conditions are associated with increased risk for fractures. Testosterone (T) has been shown to improve the bone health of hypogonadal men but has not been tested in patients who also have T2D in addition to low T. To date, there is no treatment that is specifically recommended for bone disease among patients with T2D. This study will evaluate the effect of T therapy on the bone health of male veterans with low T who also have T2D.

Methods

This is a randomized double-blind placebo-controlled trial of 166 male veterans 35-65 years old, with T2D and hypogonadism, randomized to either T gel 1.62% or placebo for 12 months. We will evaluate the effect of T therapy on the following primary ou

SUBMITTER: Russo V 

PROVIDER: S-EPMC7933702 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature