Network pharmacology-based study to explore the mechanism of the Yiqi Gubiao pill in lung cancer treatment.

ABSTRACT: Lung cancer (LC) has been one of the most prevalent and fatal malignancies in the past 5 years. Yiqi Gubiao pills have a good clinical effect against LC. However, their complex composition limits proper understanding of their pharmacological mechanism. Therefore, the present study aimed to systemically explore the underlying mechanisms of Yiqi Gubiao pills in treatment of LC. The network pharmacology approach was employed to identify the active ingredients and LC targets associated with Yiqi Gubiao pills. Prediction of potential active ingredients and action targets was then conducted through protein-protein interaction (PPI), Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses. In vitro experiments were then performed to further verify the mechanism of action

SUBMITTER: Li Z 

PROVIDER: S-EPMC7933746 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature