Obesity alters ovarian folliculogenesis through disrupted angiogenesis from increased IL-10 production.

ABSTRACT:

Objective

Obesity has been reported to have a modulatory effect on the ovulatory functions of patients with polycystic ovary syndrome. The role of adipokines in this obesity-associated ovulatory disturbance has not been extensively explored. In this study, the relationships between obesity, adipokine production from visceral fat, and ovarian folliculogenesis were explored in a mice model of induced obesity.

Methods

Obesity was induced in female C57BL/6 mice fed ad libitum with high-fat feed and fructose water for 4 weeks. Follicular developments in the ovaries were assessed by histopathology in these diet-induced obese mice. Changes in adipokine expression in the peri-ovarian adipose tissues were screened with an adipokine array. The adipokine with the most significant incre

SUBMITTER: Yang PK 

PROVIDER: S-EPMC7933796 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature