Investigating Therapies for Freezing of Gait Targeting the Cognitive, Limbic, and Sensorimotor Domains.

ABSTRACT:

Background

Freezing of gait (FOG) is arguably the most disabling motor symptom experienced with Parkinson's disease (PD), but treatments are extremely limited due to our poor understanding of the underlying mechanisms. Three cortical domains are postulated in recent research (ie, the cognitive, limbic, and sensorimotor domains), thus, treatments targeting these mechanisms of FOG may potentially be effective. Cognitive training, cognitive behavioral therapy (CBT, a well-known anxiety intervention), and proprioceptive training may address the cognitive, limbic, and sensorimotor domains, respectively.

Objective

To investigate whether these 3 treatments could improve functional outcomes of FOG.

Methods

In a single-blind, randomized crossover design, 15 individuals with PD

SUBMITTER: Chow R 

PROVIDER: S-EPMC7934156 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature