Hypermethylation of heparanase 2 promotes colorectal cancer proliferation and is associated with poor prognosis.

ABSTRACT:

Background

The epigenetic abnormality of tumor-associated genes contributes to the pathogenesis of colorectal carcinoma (CRC). However, methylation in colorectal cancer is still poorly characterized.

Method

By integration of DNA methylation data from the GEO database and gene expression data from The Cancer Genome Atlas database, the aberrantly methylated genes involved in CRC tumorigenesis were identified. Subsequent in vitro experiments further validated their role in CRC.

Results

We performed integrative genomic analysis and identified HPSE2, a novel tumor suppressor gene that is frequently inactivated through promoter methylation in CRC. K-M survival analysis showed that hypermethylation-low expression of heparanase 2 (HPSE2) was related to poor patient prognosis.

SUBMITTER: Zhang H 

PROVIDER: S-EPMC7934273 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature