Genomic analysis reveals independent evolution of Plasmodium falciparum populations in Ethiopia.

ABSTRACT:

Background

Plasmodium falciparum parasite populations in Ethiopia have been experiencing local selective pressures from drugs and immunity, leading to evolutionary adaptation. However, there was a paucity of data on genomic characterization and evolutionary adaptations of P. falciparum isolates from the central area of Ethiopia.

Methods

Whole-genome analysis of 25 P. falciparum isolates from central Ethiopia, specifically from West Arsi, were studied to determine their genetic diversity, population structures, and signatures of selection in known drug resistance alleles against global isolates from Cambodia, Thailand, DR Congo, and Malawi.

Results

A total of 18,517 high-quality single-nucleotide polymorphisms (SNPs) were identified in Ethiopian P. falciparum isolates.

SUBMITTER: Abera D 

PROVIDER: S-EPMC7934276 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature