Atezolizumab in combination with intrathecal chemotherapy and radiation for treatment of isolated cerebral nervous system relapse in a patient with extranodal NK/T cell lymphoma: a case report.

ABSTRACT:

Background

Extranodal NK/T cell lymphoma (ENKTL) is an aggressive form of Epstein-Barr virus (EBV)-associated non-Hodgkin's lymphoma which historically has a poor prognosis. When relapse occurs, particularly in the cerebral nervous system (CNS), survival is rare. The immune checkpoint pathway family of proteins is highly expressed in many human tumors, especially in EBV-related malignancies. To the best of our knowledge, there are no reports of immune checkpoint inhibitors used either alone or in combination for the treatment of ENTKL CNS relapse, yet there are promising results in metastatic CNS involvement of other malignancies.

Case presentation

This is the case of a 29-year-old Hispanic male with ENKTL who was treated at first relapse with 24 doses of the programmed deat

SUBMITTER: Lipsitt AE 

PROVIDER: S-EPMC7934377 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature