Interaction between dietary branched-chain amino acids and genetic risk score on the risk of type 2 diabetes in Chinese.

ABSTRACT:

Background and objectives

Previous studies have found the important gene-diet interactions on type 2 diabetes (T2D) incident but have not followed branched-chain amino acids (BCAAs), even though they have shown heterogeneous effectiveness in diabetes-related factors. So in this study, we aim to investigate whether dietary BCAAs interact with the genetic predisposition in relation to T2D risk and fasting glucose in Chinese adults.

Methods

In a case-control study nested in the Harbin Cohort Study on Diet, Nutrition and Chronic Non-Communicable Diseases, we obtained data for 434 incident T2D cases and 434 controls matched by age and sex. An unweighted genetic risk score (GRS) was calculated for 25 T2D-related single nucleotide polymorphisms by summation of the number of risk al

SUBMITTER: Wang W 

PROVIDER: S-EPMC7934387 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature