Proposal of initial and maintenance dosing regimens with linezolid for renal impairment patients.

ABSTRACT:

Background

Linezolid is administered as a fixed dose to all patients despite evidence of overexposure and thrombocytopenia in renal impairment. The aims of this study were to evaluate the risk of thrombocytopenia and the utility of therapeutic drug monitoring (TDM), and to propose alternate dosing regimens in patients with renal impairment.

Methods

We retrospectively reviewed patients ≥13 years old for whom serum linezolid trough concentration (C_min) was measured during linezolid treatment. Patients with episodes of infection were divided into groups by presence of renal impairment (RI group) or absence of renal impairment (non-RI group), and by use of C_min-based TDM (TDM group) or not (non-TDM group) during linezolid treatment.

Results

In the 10

SUBMITTER: Kawasuji H 

PROVIDER: S-EPMC7934392 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature