Genetic susceptibility, elevated blood pressure, and risk of atrial fibrillation: a Mendelian randomization study.

ABSTRACT:

Background

Whether elevated blood pressure (BP) is a modifiable risk factor for atrial fibrillation (AF) is not established. We tested (1) whether the association between BP and risk of AF is causal, (2) whether it varies according to individual's genetic susceptibility for AF, and (3) the extent to which specific BP-lowering drugs are expected to reduce this risk.

Methods

First, causality of association was assessed through two-sample Mendelian randomization, using data from two independent genome-wide association studies that included a population of one million Europeans in total. Second, the UK Biobank data of 329,237 participants at baseline was used to study the effect of BP on AF according to genetic susceptibility of developing AF. Third, a possible treatment effect

SUBMITTER: Nazarzadeh M 

PROVIDER: S-EPMC7934395 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature