TP53 drives abscopal effect by secretion of senescence-associated molecular signals in non-small cell lung cancer.

ABSTRACT:

Background

Recent developments in abscopal effect strongly support the use of radiotherapy for the treatment of metastatic disease. However, deeper understanding of the molecular mechanisms underlying the abscopal effect are required to best benefit a larger proportion of patients with metastasis. Several groups including ours, reported the involvement of wild-type (wt) p53 in radiation-induced abscopal effects, however very little is known on the role of wtp53 dependent molecular mechanisms.

Methods

We investigated through in vivo and in vitro approaches how wtp53 orchestrates radiation-induced abscopal effects. Wtp53 bearing (A549) and p53-null (H1299) NSCLC lines were xenotransplanted in nude mice, and cultured in 2D monolayers and 3D tumor spheroids. Extracellular vesicl

SUBMITTER: Tesei A 

PROVIDER: S-EPMC7934399 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature