Experimental and computational studies of an antiplasmodial derivative of allantoin; antimycobacterial essential oil from Cordia batesii WERNHAM (Boraginaceae).

ABSTRACT:

Background

Chemical and pharmacological investigations were performed on the stems of Cordia batesii (Boraginaeae); chemical studies included quantum calculations applied on a newly described compound.

Results

A new derivative of allantoin (1) named batesiin (2) was characterized. Thirteen other known compounds involving allantoin (1) were either isolated or identified. GC-MS enabled the identification of six compounds from a fraction containing essential oil. MeOH extract and some isolated compounds were tested in vitro against Pf7G8 CQS and Pf Dd2 CQR strains of Plasmodium falciparum; extract disclosed a moderate antiplasmodial activity (IC₅₀ = 50 μg mL^-1). Meantime, the CH₂Cl₂ extract and essential oil fraction were tested on a

SUBMITTER: Tiam ER 

PROVIDER: S-EPMC7934435 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature