DeltaNeTS+: elucidating the mechanism of drugs and diseases using gene expression and transcriptional regulatory networks.

ABSTRACT:

Background

Knowledge on the molecular targets of diseases and drugs is crucial for elucidating disease pathogenesis and mechanism of action of drugs, and for driving drug discovery and treatment formulation. In this regard, high-throughput gene transcriptional profiling has become a leading technology, generating whole-genome data on the transcriptional alterations caused by diseases or drug compounds. However, identifying direct gene targets, especially in the background of indirect (downstream) effects, based on differential gene expressions is difficult due to the complexity of gene regulatory network governing the gene transcriptional processes.

Results

In this work, we developed a network analysis method, called DeltaNeTS+, for inferring direct gene targets of drugs and

SUBMITTER: Noh H 

PROVIDER: S-EPMC7934467 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature