Predictors of a placebo response in patients with hand osteoarthritis: post-hoc analysis of two randomized controlled trials.

ABSTRACT:

Background

Placebo can have a significant therapeutic effect in patients with hand osteoarthritis (OA). This aim of the study is to identify factors associated with a clinically meaningful placebo response in patients with hand OA.

Methods

This post-hoc analysis of two double-blind, placebo-controlled, randomized trials (RCTs) investigating the efficacy of GCSB-5 or diacerein as treatments for hand OA analyzed the efficacy of a placebo. Clinical and laboratory factors associated with a clinically meaningful response, defined as an improvement in the Australian/Canadian Osteoarthritis Hand Index (AUSCAN) pain score > 10 at 4 weeks relative to baseline, were identified.

Results

The mean improvement in the AUSCAN pain score was - 6.0 ± 20.3, with marked variation between

SUBMITTER: Park JK 

PROVIDER: S-EPMC7934539 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature