Gut microbiota composition and functional prediction in diarrhea-predominant irritable bowel syndrome.

ABSTRACT:

Background

Irritable bowel syndrome (IBS) is common and difficult to treat and its pathogenesis is closely related to gut microbiota. However, differences in gut microbiota of patients in different regions make it more difficult to elucidate the mechanism of IBS. We performed an analysis of gut microbiota composition and functional prediction in Chinese patients with diarrhea-predominant IBS (IBS-D).

Methods

Fecal samples were obtained from 30 IBS-D patients and 30 healthy controls (HCs) in Nanchang, China. Using 16S gene sequence profiles, we analyzed the abundance of dominant microbiota at different taxonomy levels. Based on 16S information, Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt) was used to predicting the function of gut

SUBMITTER: Mei L 

PROVIDER: S-EPMC7934555 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature