Gut Microbiota Modulate CD8 T Cell Responses to Influence Colitis-Associated Tumorigenesis.

ABSTRACT: There is increasing evidence that gut microbiome perturbations, also known as dysbiosis, can influence colorectal cancer development. To understand the mechanisms by which the gut microbiome modulates cancer susceptibility, we examine two wild-type mouse colonies with distinct gut microbial communities that develop significantly different tumor numbers using a mouse model of inflammation-associated tumorigenesis. We demonstrate that adaptive immune cells contribute to the different tumor susceptibilities associated with the two microbial communities. Mice that develop more tumors have increased colon lamina propria CD8⁺ IFNγ⁺ T cells before tumorigenesis but reduced CD8⁺ IFNγ⁺ T cells in tumors and adjacent tissues compared with mice that develop

SUBMITTER: Yu AI 

PROVIDER: S-EPMC7934571 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature