Formalin-induced pain prolongs sub- to supra-second time estimation in rats.

ABSTRACT:

Background

Temporal estimation can be influenced by pain, which is a complex psychological and physiological phenomenon. However, the time range in which perception is most sensitive to pain remains unclear.

Methods

In the present study, we explored the effects of acute inflammatory pain on time perception in the sub- to supra-second (0.6-2.4-s) and supra-second (2-8-s) ranges in rats. Plantar formalin injection was used to induce acute inflammatory pain, and a temporal bisection task was used to measure time perception. Task test sessions were held for five consecutive days (one per day): the day before injection (baseline), immediately after injection, and the three post-injection days. The point of subjective equality (PSE, which reflects the subjective duration) and Webe

SUBMITTER: Liu X 

PROVIDER: S-EPMC7934679 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature