Synthesis and physicochemical evaluation of fluorinated lipopeptide precursors of ligands for microbubble targeting.

ABSTRACT: Ligand-targeted microbubbles are focusing interest for molecular imaging and delivery of chemotherapeutics. Lipid-peptide conjugates (lipopeptides) that feature alternating serine-glycine (SG) _n segments rather than classical poly(oxyethylene) linkers between the lipid polar head and a targeting ligand were proposed for the liposome-mediated, selective delivery of anticancer drugs. Here, we report the synthesis of perfluoroalkylated lipopeptides (F-lipopeptides) bearing two hydrophobic chains (C _n F_{2 n +1}, n = 6, 7, 8, 1-3) grafted through a lysine moiety on a hydrophilic chain composed of a lysine-serine-serine (KSS) sequence followed by 5 SG sequences. These F-lipopeptides are p

SUBMITTER: Hagimori M 

PROVIDER: S-EPMC7934786 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature