Ontology highlight
ABSTRACT:
SUBMITTER: Ostermann L
PROVIDER: S-EPMC7934856 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Ostermann Lena L Maus Regina R Stolper Jennifer J Schütte Lisanne L Katsarou Konstantina K Tumpara Srinu S Pich Andreas A Mueller Christian C Janciauskiene Sabina S Welte Tobias T Maus Ulrich A UA
JCI insight 20210208 3
Alpha-1 antitrypsin (AAT) is a major inhibitor of serine proteases in mammals. Therefore, its deficiency leads to protease-antiprotease imbalance and a risk for developing lung emphysema. Although therapy with human plasma-purified AAT attenuates AAT deficiency-related emphysema, its impact on lung antibacterial immunity is poorly defined. Here, we examined the effect of AAT therapy on lung protective immunity in AAT-deficient (KO) mice challenged with Streptococcus pneumoniae. AAT-KO mice were ...[more]