B cells modulate mouse allergen-specific T cells in nonallergic laboratory animal-care workers.

ABSTRACT: Understanding the mechanisms of allergen-specific immune modulation in nonallergic individuals is key to recapitulate immune tolerance and to develop novel allergy treatments. Herein, we characterized mouse-specific T cell responses in nonallergic laboratory animal-care workers before and after reexposure to mice. PBMCs were collected and stimulated with developed peptide pools identified from high-molecular-weight fractions of mouse allergen extracts. Sizable CD4 T cell responses were noted and were temporarily decreased in most subjects upon reexposure, with the magnitude of decrease positively correlated with time of reexposure but not the duration of the break. Interestingly, the suppression was specific to mouse allergens without affecting responses of bystander antigens. Further, PBM

SUBMITTER: Yu ED 

PROVIDER: S-EPMC7934936 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature