A covariate-constraint method to map brain feature space into lower dimensional manifolds.

ABSTRACT: Human brain connectome studies aim to both explore healthy brains, and extract and analyze relevant features associated with pathologies of interest. Usually this consists of modeling the brain connectome as a graph and using graph metrics as features. A fine brain description requires graph metrics computation at the node level. Given the relatively reduced number of patients in standard cohorts, such data analysis problems fall in the high-dimension, low-sample-size framework. In this context, our goal is to provide a machine learning technique that exhibits flexibility, gives the investigator an understanding of the features and covariates, allows visualization and exploration, and yields insight into the data and the biological phenomena at stake. The retained approach is dimension red

SUBMITTER: Renard F 

PROVIDER: S-EPMC7935034 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature