Dynamic community detection reveals transient reorganization of functional brain networks across a female menstrual cycle.

ABSTRACT: Sex steroid hormones have been shown to alter regional brain activity, but the extent to which they modulate connectivity within and between large-scale functional brain networks over time has yet to be characterized. Here, we applied dynamic community detection techniques to data from a highly sampled female with 30 consecutive days of brain imaging and venipuncture measurements to characterize changes in resting-state community structure across the menstrual cycle. Four stable functional communities were identified, consisting of nodes from visual, default mode, frontal control, and somatomotor networks. Limbic, subcortical, and attention networks exhibited higher than expected levels of nodal flexibility, a hallmark of between-network integration and transient functional reorganization.

SUBMITTER: Mueller JM 

PROVIDER: S-EPMC7935041 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature